The ambulance was traveling south on South Bishop Avenue near Baltimore Pike when it was struck by an unknown vehicle around 5 a.m., Springfield Township police said.
The ambulance was pushed off the road and hit a tree, police said.
It was not immediately known if the ambulance was responding to an emergency call or if anyone was hurt.
Anyone with information on the incident is urged to contact Sgt. J. DiTrolio at 610-544-5507.
Click here to follow Daily Voice Drexel Hill-Upper Darby and receive free news updates.