It happened around 8:40 p.m. Tuesday, April 26 in Medford.
Edward A. Thornlow, age 54, of Shirley, was driving a 2014 Cadillac sedan westbound in the eastbound lanes of Express Drive South, Suffolk County Police said.
The vehicle then collided with a 2020 Ford Transit 350, being driven southbound on Horseblock Road by Christopher J. Samson, age 58, of Bayport, according to police.
Thornlow was transported to Stony Brook University Hospital where he was pronounced dead, said police.
Samson was transported to Long Island Community Hospital in Patchogue for treatment of minor injuries, according to police.
Click here to follow Daily Voice Brentwood and receive free news updates.