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Harrisburg Bureau of fire crews were called to the fire in the 2400 block of Reel Street at 8:10 p.m., according to dispatchers and the bureau's Facebook.
The fire quickly spread to seven homes and seriously damaged four of them, fire officials say.
Off-duty fire staff was called to help battle the blaze, which was knocked down by 8:55 p.m., Chief Brian Enterline told the press.
Forty-four people in total were displaced— 18 adults and 26 children, who are being cared for by the American Red Cross of Greater PA.
The fire remains under investigation and the costs of damages are still unknown.
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