Firefighters were met by a raging blaze at what had once been Davis & Sons at the corner of 19th Avenue and East 23rd Street across from Public School #24 around 10 p.m. Thursday.
Flames blew through the dilapidated 2½-story wood-frame house and extended to single-story brick additions on either side, posing severe challenges.
No serious injuries were immediately reported.
Fire command reported shortly after 1 a.m. Friday that it would be an extended operation, with relief companies rotating through the overnight.
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