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Noel Rosado of Allentown, who turned 50 on Friday, was taken to Helene Fuld Medical Center, New Jersey State Trooper Alejandro Goez said.
Rosado was driving a Lexus RC 350 about 9:50 p.m. on Thursday when he ran off of I-195 and into the righthand guardrail, Goez said.
The Lexus crossed back over all the lanes near mile-marker 6.9 and ran into a concrete barrier, Goez said.
The cause of the crash has not been determined, he said.
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