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Firefighters responded to the 600 block of Linden Avenue just before 1 a.m., where they found the house engulfed in flames, officials said.
Abigail Kaufman, 10, and Brianna Baer, 15, were trapped in the blaze and later rescued by firefighters, but they died at St Luke's Hospital in Bethlehem, according to the Lehigh County Coroner's Office.
An older man and woman escaped the blaze unharmed, LehighValleyLive reports.
Autopsies are scheduled for Monday, April 4, the coroner's office said.
The cause of the fire remains under investigation by the Hellertown Police Department, Dewey Fire Company, and Pennsylvania State Police Fire Marshall.
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