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The wreck was reported around 12:40 p.m. on I-78 eastbound at mile marker 61 in Upper Saucon Township, PA State Police Trooper Nathan Branosky said on Twitter.
It was not immediately clear if there were any injuries.
The left lane was closed and traffic was moving in the right lane, he said.
A 511PA traffic camera shows the trailer on the ground blocking the left and middle lanes.
A tow truck was on the scene as of 2 p.m.
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