It happened around 4:10 p.m. Wednesday, Sept. 11, in Setauket.
The driver of the Forester was transported via ambulance to Stony Brook University Hospital for treatment of serious physical injuries.
The driver of the Toyota, a 33-year-old Setauket man, and an adult passenger in the Subaru were transported to the same hospital for treatment of minor injuries.
Detectives are asking anyone with information on this crash to contact Sixth Squad detectives at 631-854-8652.
Check back to Daily Voice for updates.
Click here to follow Daily Voice Saint James-Nesconset and receive free news updates.