The accident resulted in the closure of the eastbound lanes for approximately five hours.
A state police investigation revealed that a white Toyota Highlander, which was traveling westbound, crossed into the center grassy median and into the eastbound lanes of travel where it was struck by a tractor-trailer which was traveling eastbound.
A passenger in the Toyota was pronounced deceased at the scene, state police said.
The driver of the tractor-trailer suffered minor injuries, was transported to a local hospital, treated and released. The driver of the Toyota suffered internal injuries and was stat flighted to Westchester Medical Center where he remains in critical condition.
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