The crash occurred on Route 15 northbound near milepost 19.3 in Lafayette shortly before 12:35 a.m., NJSP Sgt. Philip Curry told Daily Voice.
One of the drivers was flown to Morristown Medical Center with non-life-threatening injuries.
Two passengers were taken to the hospital by ground ambulance, the Sgt. added.
No further details were released.
Click here to follow Daily Voice North Hunterdon and receive free news updates.