Holyoke police were called to Appleton Street just before 9:30 a.m., suffering a gunshot wound. He died at the scene soon after, authorities said.
Investigators have not released the man's name.
Police have released scant details about the shooting so far.
Holyoke detectives and the Hampden District Attorney's Office is investigating.
Officers ask anyone with information on the shooting to call 413-322-6900.
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