The two crash happened in Lurgan Township, Franklin County shortly before 6 a.m., according to state police Trooper Megan Ammerman.
One man died on the scene and another was flown to Penn State Holy Spirit Hospital, reports Fox 43 citing officials.
The crash closed Route 641 just north of Lower Horse Valley Road for several hours, reopening at around 9:30 a.m., according to Trooper Ammerman.
Follow Daily Voice for updates.
Click here to follow Daily Voice Gettysburg and receive free news updates.