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The Quakertown Fire Company, EMS and HMC paramedics responded to the crash off Everittstown Road in Alexandria around 5:40 p.m., firefighters said.
There, they found two people with multiple injuries. The victims were taken in an off-road transport vehicle to a landing zone at Sky Manor Airport, where medical chopper awaited.
Both victims were flown to Robert Wood Johnson Hospital in New Brunswick.
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