The crash happened on the southbound Seaford-Oyster Bay Expressway in Bethpage on Thursday, July 28, the Nassau County Police Department said.
A 2020 Subaru left the roadway and hit a tree between exits 9 and 10 at about 4:50 a.m., NCPD reported.
Police said the driver was pronounced dead by a Nassau County Police Medic.
NCPD did not release the man's identity.
There were no other occupants in the Subaru, police said.
Click here to follow Daily Voice Suffolk and receive free news updates.