The Section 1 champion Red Devils trailed by 13 points at halftime and got as close as 41-32 midway through the third quarter but could not break through Maine-Enwell's tight defense and strong inside offensive game.
Lanay Rodney led Peekskill with 16 points, 10 in the second half.
Maine-Enwell advanced to the New York State Public High Schools Athletic Association championship Final four and will play a semfinal game next Saturday, March 15 at Hudson Valley Community College in upstate Troy.
The Red Devils won their second consecutive Section 1 title last week.
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