The crash happened near Exit 2 on I-93 North in Canton on Wednesday morning, Feb. 22, according to MassDOT.
The crash and spill closed all northbound lanes as well as the ramp from I-95 to I-93, Massachusetts State Police said on Twitter.
"The spill is significant and will be a long clean up," State Police said.
People were being told to seek alternate routes as a result. No word yet on any injuries.
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