Daneayah and Daneajah Johnson, both 16, were last seen in Port Jefferson Station on Saturday, Aug. 9, according to the New York State Missing Persons Clearinghouse.
Daneayah was wearing a black shirt, gray pants, and gray Jordan shoes, while Daneajah had a blue sweater, black sweatpants, and slippers.
The girls may have traveled to Philadelphia, police said.
Anyone with information is asked to call 1-800-346-3543.
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