The closure is westbound at Exit 46 in Woodbury.
The northbound Seaford Oyster Bay Expressway exit to the LIE westbound is also closed.
Both closures are due to the crash on the LIE.
Motorists can expect delays and should avoid the area, Nassau County Police said just before 1 p.m. Wednesday.
The lanes remain closed during the accident investigation late in the afternoon.
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