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It happened on Monday, May 11 just before 11:15 p.m. on the eastbound expressway, between Exits 48 and 49 in Melville.
The man was driving a 2016 Chrysler Town and Country when the vehicle left the roadway and struck a pole, Suffolk County Police said.
The man, who has not yet been identified by police, was pronounced dead at the scene by a physician assistant from the Suffolk County Medical Examiner's office.
The vehicle was impounded for a safety check. Detectives are asking anyone with information on the crash to contact the Second Squad at 631-854-8252.
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