The crash occurred at 12:12 a.m. near milepost 5.5 on Route 632 (Asbury Anderson Road) in Franklin Township, according to New Jersey State Police.
State Police said a Ford 500 sedan was traveling east on Route 632 when it traveled off the road to the right and struck multiple trees.
The driver, a 28-year-old woman from Franklin Township, was seriously injured, police said.
A medical helicopter transported the woman to Morristown Medical Center. they said.
The crash remains under investigation.
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