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The stretch on Route 22 eastbound at Route 145 in South Whitehall was closed at 3 p.m., according to a tweet from Pennsylvania State Police Trooper Nathan Branosky.
Tpr. Branosky did not detail how many injuries there were as a result of the crash.
He confirmed the left lane reopened around 3:50 p.m.
The traffic is moving, according to a 511PA traffic camera.
The cause of the crash was not immediately known.
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